Manolis Pasparakis - Genetic Mutations

Author Information

Manolis Pasparakis is affiliated with the Institute for Genetics at the University of Cologne, Cologne, Germany. His research focuses on various aspects of genetics, including the molecular mechanisms of inflammation, cell death, and immunity.

Research Contributions

Manolis Pasparakis has made significant contributions to the field of genetics through his extensive research on inflammation, cell death pathways, and immune responses. His recent work includes studies on the SARS-CoV-2 main protease Mpro causing microvascular brain pathology, the role of Gasdermin D in Mycobacterium tuberculosis-infected macrophages, and the mechanisms of necroptosis in skin and airway epithelial cells. His research also encompasses the recruitment of dendritic cell progenitors in influenza A virus infection and the role of OTULIN in inhibiting keratinocyte necroptosis to prevent skin inflammation.

Aliases

M Pasparakis, M. Pasparakis, Manolis Pasparakis

Publication and Citation Metrics

Metric	Value
Citation Count	34832
h-index	91
Paper Count	286

Publications:

The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

DOI: 10.1038/s41593-021-00926-1

Year: 2021

Abstracts of the 87th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) with contribution of the Arbeitsgemeinschaft für Angewandte Humanpharmakologie e. V. (AGAH).

DOI:

Year: 2021

Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages

DOI: 10.1038/s41420-021-00716-5

Year: 2021

NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation

DOI: 10.26508/lsa.202000956

Year: 2021

Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity

DOI: 10.1126/sciimmunol.abi9331

Year: 2021

Concern over use of the term Z-DNA.

DOI: 10.1038/d41586-021-01595-7

Year: 2021

OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice

DOI: 10.1038/s41467-021-25945-1

Year: 2021

Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF

DOI: 10.1084/jem.20210862

Year: 2021

Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation

DOI: 10.1038/s41385-021-00415-5

Year: 2021

CCR2 deficiency in monocytes impairs angiogenesis and functional recovery after ischemic stroke in mice

DOI: 10.1177/0271678X20909055

Year: 2020

How are Missense Mutations Detected?

How Does Sickle Cell Disease Affect Population Genetics?

How Does Gene Amplification Occur?

Can Synonymous Mutations Be Harmful?

What Role Do Genetic Mutations Play in Prenatal Screening?

What are the Ethical Considerations Surrounding Induced Mutations?

What Types of Genetic Mutations Can Be Treated?

What Measures Can Be Taken to Mitigate the Risks?

Are There Any Ongoing Research Efforts?

What is Cancer Genomics?

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