Defective Dna Repair Processes - Genetic Mutations

Relevant Publications

Whole‑exome sequencing reveals Lewis lung carcinoma is a hypermutated Kras/Nras-mutant cancer with extensive regional mutation clusters in its genome.

Issue Release: 2024

Whole-exome sequencing reveals novel genomic signatures and potential therapeutic targets during the progression of rectal neuroendocrine neoplasm.

Issue Release: 2024

Robust discovery of mutational signatures using power posteriors.

Issue Release: 2024

Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation.

Issue Release: 2024

KU70 and CAF-1 in Arabidopsis: Divergent roles in rDNA stability and telomere homeostasis.

Issue Release: 2024

A Novel Regulatory Motif at the Hinge Dimer Interface of the MksB Mediates Dimerization and DNA Binding Activity.

Issue Release: 2024

Deregulated intracellular pathways define novel molecular targets for HBV-specific CD8 T cell reconstitution in chronic hepatitis B.

Issue Release: 2023

Stepwise requirements for polymerases δ and θ in theta-mediated end joining.

Issue Release: 2023

The fructose-bisphosphate, Aldolase A (ALDOA), facilitates DNA-PKcs and ATM kinase activity to regulate DNA double-strand break repair.

Issue Release: 2023

Histone and DNA Methylation as Epigenetic Regulators of DNA Damage Repair in Gastric Cancer and Emerging Therapeutic Opportunities.

Issue Release: 2023

Targeting BAP1 with small compound inhibitor for colon cancer treatment.

Issue Release: 2023

Differential requirement for BRCA1-BARD1 E3 ubiquitin ligase activity in DNA damage repair and meiosis in the Caenorhabditis elegans germ line.

Issue Release: 2023

DNA Damage Response Mechanisms in Head and Neck Cancer: Significant Implications for Therapy and Survival.

Issue Release: 2023

Targeted therapy of advanced parathyroid carcinoma guided by genomic and transcriptomic profiling.

Issue Release: 2023

Mismatch repair operates at the replication fork in direct competition with mismatch extension by DNA polymerase δ.

Issue Release: 2023

Chromatin remodeling enzyme Snf2h is essential for retinal cell proliferation and photoreceptor maintenance.

Issue Release: 2023

RAD51-WSS1-dependent genetic pathways are essential for DNA-Protein crosslink repair and pathogenesis in Candida albicans.

Issue Release: 2023

Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance.

Issue Release: 2023

Causes and consequences of DNA single-strand breaks.

Issue Release: 2023

Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice.

Issue Release: 2022

How Are Nucleotide Mutations Detected?

How Does Asbestos Lead to Genetic Mutations?

How are Neurodevelopmental Disorders Linked to Genetics?

What Are the Consequences of Transversions?

How Do Deletion Mutations Occur?

What is the Future of Hemoglobin Electrophoresis?

Can RNA Interference Help?

Can Genetic Testing Help Diagnose Fertility Issues?

What are the Applications of Induced Mutations in Agriculture?

Can Infectious Diseases Cause Genetic Mutations?

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