Lude H Franke - Genetic Mutations

Author Information

Lude H. Franke is a prominent researcher in the field of genetics, affiliated with the Department of Genetics at the University Medical Centre Groningen in Groningen, The Netherlands. His extensive research contributions have significantly advanced our understanding of genetic mechanisms and their implications for human health.

Research Contributions

Lude H. Franke has made substantial contributions to the field of genetics, with a particular focus on single-cell genomics, gene co-expression, and functional genomics. In 2022 alone, he has co-authored several significant papers, including works on demultiplexing single-cell data, identifying genetic variants impacting gene co-expression, and exploring the genetic underpinnings of diseases such as amyotrophic lateral sclerosis (ALS). His research has also delved into the biological mechanisms of ovarian aging and the mental health impacts of COVID-19 lockdowns, highlighting his diverse interests and expertise.

Aliases

Lude H. Franke is also known by several aliases, including L. Franke, Lude Franke, and L. H. Franke.

Publication and Citation Metrics

Metric	Value
Citation Count	46,935
H-index	85
Paper Count	265

Publications:

Demuxafy: Improvement in droplet assignment by integrating multiple single-cell demultiplexing and doublet detection methods

DOI: 10.1101/2022.03.07.483367

Year: 2022

Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data

DOI: 10.1101/2022.04.20.488925

Year: 2022

Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression

DOI: 10.1186/s13059-021-02585-8

Year: 2022

OTTERS: A powerful TWAS framework leveraging summary-level reference data

DOI: 10.1101/2022.03.30.486451

Year: 2022

Idéfix: identifying accidental sample mix-ups in biobanks using polygenic scores

DOI: 10.1093/bioinformatics/btab783

Year: 2022

Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

DOI: 10.1038/s41588-022-01020-3

Year: 2022

Genetic insights into biological mechanisms governing human ovarian ageing.

DOI: 10.1038/s41586-021-03779-7

Year: 2021

Retraction Note: Detection and replication of epistasis influencing transcription in humans.

DOI: 10.1038/s41586-021-03766-y

Year: 2021

Gender differences in the mental health impact of the COVID-19 lockdown: Longitudinal evidence from the Netherlands

DOI: 10.1016/j.ssmph.2021.100878

Year: 2021

Phantom epistasis between unlinked loci.

DOI: 10.1038/s41586-021-03765-z

Year: 2021

Why are Induced Mutations Important in Research?

Do Synonymous Mutations Affect Gene Expression?

How are Mutations Detected?

What is Radiation?

What is the CFTR Gene?

What Are the Treatment Options for Sickle Cell Disease?

How is Benzene Exposure Related to Genetic Mutations?

What is an Insertion Mutation?

How Does Genetic Counseling Assist During Pregnancy?

What are the Current Therapeutic Innovations?

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