Steven Horvath - Genetic Mutations

Author Information

Steven Horvath is a prominent researcher affiliated with the Department of Human Genetics at the David Geffen School of Medicine, University of California, Los Angeles (UCLA). His work primarily revolves around the field of genetics, with a special focus on epigenetics and aging. His research contributions have significantly advanced our understanding of the genetic and epigenetic mechanisms underlying aging and age-related diseases.

Research Contributions

Steven Horvath has made substantial contributions to the field of genetics, particularly in the study of DNA methylation and epigenetic clocks. His recent papers cover a wide array of topics, including differential methylation in small mammals, epigenetic clocks in marsupials, methylation profiling in mammals, and the role of DNA methylation in conditions like Hutchinson-Gilford Progeria syndrome. His research also delves into the impact of HIV on epigenetic age acceleration, genetic loci associated with epigenetic aging in mice, and the causal role of epigenetic clocks in cancer development. Furthermore, he has explored the association between plasma lipid profiles and epigenetic aging, as well as the effects of rapamycin treatment on lifespan and healthspan.

Aliases

S Horvath, S. Horvath, Steve Horvath, Steven Horvath

Publication and Citation Metrics

Citation Count	67,425
h-index	120
Paper Count	547

Publications:

Differential methylation, epigenetic clocks, and island-mainland divergence in an insectivorous small mammal

DOI: 10.1101/2022.04.14.488253

Year: 2022

Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies.

DOI: 10.1007/s11357-022-00569-5

Year: 2022

A mammalian methylation array for profiling methylation levels at conserved sequences

DOI: 10.1038/s41467-022-28355-z

Year: 2022

DNA methylation signatures in Blood DNA of Hutchinson–Gilford Progeria syndrome

DOI: 10.1111/acel.13555

Year: 2022

HIV, pathology and epigenetic age acceleration in different human tissues.

DOI: 10.1007/s11357-022-00560-0

Year: 2022

Genetic loci and metabolic states associated with murine epigenetic aging.

DOI: 10.7554/eLife.75244

Year: 2022

Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study.

DOI: 10.7554/eLife.75374

Year: 2022

Plasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study

DOI: 10.1186/s13148-021-01222-2

Year: 2022

Rapamycin treatment during development extends lifespan and healthspan

DOI: 10.1101/2022.02.18.481092

Year: 2022

OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases

DOI: 10.1101/2021.11.29.470428

Year: 2022

What is the future of research in inherited genetic mutations?

What is Hypothyroidism?

What is Genetic Research?

Can Mutations Be Treated or Reversed?

How Do Deletion Mutations Occur?

Are All Silent Mutations Neutral?

What is the Prognosis for Individuals with Cystic Fibrosis?

What is the Evolutionary Significance of Gene Amplification?

How are Mutations Detected?

Who Should Consider PARP Inhibitors?

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