Tom P Brew - Genetic Mutations

Author Information

Tom P. Brew is affiliated with the Cancer Genetics Laboratory, Centre for Translational Cancer Research (Te Aho Matatū), Department of Biochemistry, University of Otago, Dunedin 9016, New Zealand. His research primarily focuses on understanding the genetic and molecular mechanisms underlying cancer, with a particular emphasis on E-Cadherin-deficient cells and their vulnerabilities.

Research Contributions

Tom P. Brew has made significant contributions to the field of cancer genetics, particularly in understanding the role of E-Cadherin in cancer progression and identifying potential therapeutic targets. His research has explored various aspects of cellular vulnerabilities in E-Cadherin-deficient cells, including sphingolipid metabolism, vesicle trafficking, plasma membrane organization, and GPCR signaling. Brew's work also includes modeling hereditary diffuse gastric cancer using advanced techniques such as transgenic mouse-derived gastric organoids and single-cell sequencing.

Aliases

Tom P. Brew

Publication and Citation Metrics

Metric	Value
Citation Count	267
H-Index	6
Paper Count	7

Publications:

Loss of E-Cadherin Leads to Druggable Vulnerabilities in Sphingolipid Metabolism and Vesicle Trafficking

DOI: 10.3390/cancers14010102

Year: 2021

E-Cadherin-Deficient Epithelial Cells Are Sensitive to HDAC Inhibitors

DOI: 10.3390/cancers14010175

Year: 2021

Modelling hereditary diffuse gastric cancer initiation using transgenic mouse‐derived gastric organoids and single‐cell sequencing

DOI: 10.1002/path.5675

Year: 2021

Hereditary diffuse gastric cancer: updated clinical practice guidelines.

DOI: 10.1016/s1470-2045(20)30219-9

Year: 2020

Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells

DOI: 10.3390/cancers11091359

Year: 2019

E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function

DOI: 10.1007/s10120-018-0859-1

Year: 2018

Synthetic Lethal Screens Identify Vulnerabilities in GPCR Signaling and Cytoskeletal Organization in E-Cadherin–Deficient Cells

DOI: 10.1158/1535-7163.MCT-14-1092

Year: 2015

What Are Some Common Developmental Disorders Linked to Genetic Mutations?

Why are Induced Mutations Important in Research?

What is Data Analysis in Genetic Mutations?

How Do Mutations in Non-Coding Regions Affect Gene Expression?

What are the Implications for Carriers?

What is Populace Genomics?

What Ethical Considerations Arise From Genetic Research?

What Role Do Genes Play in Brain Development?

What is Genetic Coding?

What is Hypothyroidism?

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