David a. Hafler - Genetic Mutations

Author Information

David A. Hafler is a prominent researcher in the field of neurology, affiliated with the Department of Neurology at Yale School of Medicine in New Haven, Connecticut, USA. His work is particularly influential in understanding the genetic and immunological aspects of various neurological diseases. His research often utilizes advanced techniques such as single-cell sequencing and multi-omics to uncover insights into complex conditions like Parkinson's disease, COVID-19, and cancer immunology.

Research Contributions

David A. Hafler has made significant contributions to the field of genetics and neurology, with recent publications focusing on single-cell transcriptomic and proteomic analyses of diseases such as Parkinson's and COVID-19. His work on Spatial-CITE-seq has provided deeper insights into spatially resolved protein and transcriptome co-mapping. Additionally, his research delves into the immune system's role in disease progression, including the regulation of coinhibitory receptors in T cells and the characterization of B cell repertoires in COVID-19 patients. His efforts in population genetics and single-cell sequencing have further expanded the understanding of genetic influences on disease.

Aliases

David A. Hafler is known by several aliases in the academic community, including D. A. Hafler, David Hafler, D. Hafler, and D A Hafler, among others. These variations may appear in different publications and databases.

Publication and Citation Metrics

Metric	Value
Total Citation Count	69,104
H-index	129
Total Paper Count	718

Publications:

Single-cell transcriptomic and proteomic analysis of Parkinson’s disease Brains

DOI: 10.1101/2022.02.14.480397

Year: 2022

Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19

DOI: 10.1038/s41467-021-27716-4

Year: 2022

Spatial-CITE-seq: spatially resolved high-plex protein and whole transcriptome co-mapping

DOI: 10.21203/rs.3.rs-1499315/v1

Year: 2022

Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain.

DOI: 10.1038/s41593-022-01022-8

Year: 2022

Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells.

DOI: 10.1038/s41590-022-01152-y

Year: 2022

TCR-sequencing in cancer and autoimmunity: barcodes and beyond.

DOI: 10.1016/j.it.2022.01.002

Year: 2022

Spatial-CITE-seq: spatially resolved high-plex protein and whole transcriptome co-mapping

DOI: 10.1101/2022.04.01.486788

Year: 2022

Population genetics meets single-cell sequencing.

DOI: 10.1126/science.abq0426

Year: 2022

Phase 2 Trial of Rituximab in Acetylcholine Receptor Antibody-Positive Generalized Myasthenia Gravis

DOI: 10.1212/WNL.0000000000013121

Year: 2022

Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19

DOI: 10.4049/jimmunol.2100135

Year: 2021

What is the Impact of Missense Mutations?

What is Immunotherapy?

What Are the Consequences of Gene Amplification?

How Does Gene Amplification Occur?

How is Gene Amplification Detected?

What are the Treatment Options for Sickle Cell Anemia?

What is Gene Amplification?

Is There a Cure for Autism Spectrum Disorder?

Is All Evolution Neutral?

Is Genetic Counseling Recommended?

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