Lesley Probert - Genetic Mutations

Author Information

Lesley Probert is affiliated with the Laboratory of Molecular Genetics at the Hellenic Pasteur Institute, located in Athens, Greece. Her research primarily focuses on the molecular and genetic aspects of neurological disorders, with a special emphasis on neuroimmunology and the pathophysiology of diseases such as multiple sclerosis and myelodysplastic syndrome.

Research Contributions

Lesley Probert has made significant contributions to the field of genetics, particularly in understanding the mechanisms underlying central nervous system (CNS) pathologies. Her work has explored the roles of hypoxia-inducible factors and pseudohypoxia in myelodysplastic syndrome, as well as the function of neuronal TNF receptors in CNS pathology. Through a series of studies, she has investigated the dynamics of microglial responses in demyelination and the potential therapeutic strategies for multiple sclerosis. Her research has also addressed the impact of inflammation and oxidative stress on the development of therapies for multiple sclerosis.

Aliases

Lesley Probert is also known by various aliases, including L A Probert, L Probert, and L. Probert. These aliases are used in academic publications and citations.

Publication and Citation Metrics

Metric	Value
Citation Count	7924
H-index	40
Paper Count	120

Publications:

Exploiting the Role of Hypoxia-Inducible Factor 1 and Pseudohypoxia in the Myelodysplastic Syndrome Pathophysiology

DOI: 10.3390/ijms22084099

Year: 2021

Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice

DOI: 10.1186/s12974-021-02200-4

Year: 2021

Novel cell-based analysis reveals region-dependent changes in microglial dynamics in grey matter in a cuprizone model of demyelination

DOI: 10.1016/j.nbd.2021.105449

Year: 2021

A National Representative, Cross-Sectional Study by the Hellenic Academy of NeuroImmunology (HEL.A.NI.) on COVID-19 and Multiple Sclerosis: Overall Impact and Willingness Toward Vaccination

DOI: 10.3389/fneur.2021.757038

Year: 2021

Fundamentally Different Roles of Neuronal TNF Receptors in CNS Pathology: TNFR1 and IKKβ Promote Microglial Responses and Tissue Injury in Demyelination, TNFR2 Protects in Excitotoxicity in Mice

DOI: 10.21203/rs.3.rs-136877/v1

Year: 2021

Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development

DOI: 10.1155/2020/7191080

Year: 2020

Characterization of Asparagine Deamidation in Immunodominant Myelin Oligodendrocyte Glycoprotein Peptide Potential Immunotherapy for the Treatment of Multiple Sclerosis

DOI: 10.3390/ijms21207566

Year: 2020

Editorial: Update on Translational Neuroimmunology - Research of ISNI 2018

DOI: 10.3389/fimmu.2020.02012

Year: 2020

Mannan-MOG35-55 Reverses Experimental Autoimmune Encephalomyelitis, Inducing a Peripheral Type 2 Myeloid Response, Reducing CNS Inflammation, and Preserving Axons in Spinal Cord Lesions

DOI: 10.3389/fimmu.2020.575451

Year: 2020

A Cyclic Altered Peptide Analogue Based on Myelin Basic Protein 87–99 Provides Lasting Prophylactic and Therapeutic Protection Against Acute Experimental Autoimmune Encephalomyelitis

DOI: 10.3390/molecules23020304

Year: 2018

Which Genes are Involved in Autism Spectrum Disorder?

Are There Risks of Genetic Mutations in Sickle Cell Patients Using Hydroxyurea?

Can Mutations in Non-Coding Regions Cause Diseases?

What is the Neutral Theory?

What is Epigenetics?

What is Autosomal Recessive Inheritance?

What Are the Advantages of Third Generation Sequencing Over Previous Methods?

What Role Does Genetic Testing Play in Managing Infectious Diseases?

How do ZFNs function?

Can the body repair PAH-induced DNA damage?

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