What Are the Mechanisms Behind Benzene-Induced Mutations?
Several mechanisms contribute to benzene-induced genetic mutations:
DNA Adduct Formation: Benzene metabolites can form covalent bonds with DNA, creating DNA adducts that lead to replication errors. Oxidative Stress: Benzene metabolism generates reactive oxygen species (ROS), which can cause oxidative damage to DNA, proteins, and cell membranes. Chromosomal Aberrations: Benzene exposure can induce chromosomal breakage, deletions, and translocations, disrupting normal genetic function.
