Are There Limitations to Hemoglobin Electrophoresis?
While hemoglobin electrophoresis is a powerful diagnostic tool, it has limitations. It may not detect all types of hemoglobin variants, especially those present in very low concentrations. Additionally, it cannot provide information about the specific genetic mutations responsible for the observed hemoglobin patterns. For comprehensive diagnosis, electrophoresis is often combined with other techniques such as DNA sequencing or PCR amplification.
