What is the Genetic Advantage of Sickle Cell Trait?
Interestingly, individuals with sickle cell trait have a genetic advantage in regions where malaria is prevalent. The presence of one mutated HBB gene provides some protection against malaria, as the sickle-shaped cells can inhibit the malaria parasite's life cycle. This evolutionary advantage explains the higher prevalence of the sickle cell mutation in malaria-endemic regions.
