Paul Laissue - Genetic Mutations

Author Information

Paul Laissue is affiliated with the Center For Research in Genetics and Genomics (CIGGUR), GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, located in Bogotá, Colombia. His research primarily focuses on genetics and genomics, involving a diverse range of genetic studies and investigations.

Research Contributions

Paul Laissue has made significant contributions to the field of genetics, with a particular focus on pharmacogenetics, genetic mutations related to various medical conditions, and structural modeling of proteins. His work includes investigating the genetic profiles of breast cancer in Colombian women, whole-exome sequencing related to Stevens-Johnson syndrome and toxic epidermal necrolysis, and pharmacogenetic studies in acute coronary syndrome and epilepsy patients. Laissue has also explored the molecular mechanisms behind conditions like preeclampsia and disorders of sex development, enhancing our understanding of these complex diseases.

Aliases

Paul Laissue is also known by the aliases P. Laissue and P Laissue.

Publication and Citation Metrics

Metric	Value
Citation Count	2522
H-Index	25
Paper Count	99

Publications:

Abstract P3-07-05: Genetic profile of germline mutations in unselected women with breast cancer in a Colombian population

DOI: 10.1158/1538-7445.sabcs21-p3-07-05

Year: 2022

Whole-Exome Sequencing in Patients Affected by Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Reveals New Variants Potentially Contributing to the Phenotype

DOI: 10.2147/PGPM.S289869

Year: 2021

A Pharmacogenetic Study of CYP2C19 in Acute Coronary Syndrome Patients of Colombian Origin Reveals New Polymorphisms Potentially Related to Clopidogrel Therapy

DOI: 10.3390/jpm11050400

Year: 2021

Structural Modelling of KCNQ1 and KCNH2 Double Mutant Proteins, Identified in Two Severe Long QT Syndrome Cases, Reveals New Insights into Cardiac Channelopathies

DOI: 10.3390/ijms222312861

Year: 2021

Protocol of Whole-exome sequencing in patients affected by Stevens-Johnson syndrome and toxic epidermal necrolysis. v1

DOI: 10.17504/protocols.io.bk7vkzn6

Year: 2020

Molecular Mechanisms of Trophoblast Dysfunction Mediated by Imbalance between STOX1 Isoforms

DOI: 10.1016/j.isci.2020.101086

Year: 2020

Exploring the Molecular Aetiology of Preeclampsia by Massive Parallel Sequencing of DNA

DOI: 10.1007/s11906-020-01039-z

Year: 2020

A Pharmacogenomic Dissection of a Rosuvastatin-Induced Rhabdomyolysis Case Evokes the Polygenic Nature of Adverse Drug Reactions

DOI: 10.2147/PGPM.S228709

Year: 2020

Possible Genetic Determinants of Response to Phenytoin in a Group of Colombian Patients With Epilepsy

DOI: 10.3389/fphar.2020.00555

Year: 2020

DHH pathogenic variants involved in 46,XY disorders of sex development differentially impact protein self-cleavage and structural conformation

DOI: 10.1007/s00439-020-02189-5

Year: 2020

How are CNVs Detected?

What Are the Potential Consequences of Radiation-Induced Mutations?

What are Missense Mutations?

Do Genetic Mutations Always Have Positive Effects?

What are the Signs of BRCA1 and BRCA2 Mutations?

What Tools are Used to Analyze CNVs?

How are Inherited Mutations Detected?

What is PacBio?

How Are Mutagens Detected?

What Types of Mutations Occur in the CFTR Gene?

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